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Corticosterone treatment of adult hippocampal NSC cultures induced ACD via SGK3 (serum/glucocorticoid regulated kinase 3) without signs of apoptosis Our results demonstrate that ACD is biologically important in a mammalian system in vivo and would be an attractive target for therapeutic intervention for psychological stressinduced disorders. ATF6 activating transcription factor 6;. ACD ΔRD induced autophagic flux (Fig 6E) and chromosome fusions (Fig 6F) However, comparable numbers of fusions were observed in response to ACD ΔRD expression independently of the autophagy status in Atg5 / and atg5 −/as well as in Atg7 / and atg7 −/MEFs (Fig 6G, data not shown).
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